2. PROTAC
  3. PROTAC Linkers
  4. Azido-PEG1

Azido-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Azido-PEG1 Chemical Structure

Azido-PEG1 Chemical Structure

CAS No. : 1517-05-1

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Based on 1 publication(s) in Google Scholar

Azido-PEG1 Related Antibodies

Top Publications Citing Use of Products

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

Azido-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azido-PEG1 Related Antibodies
Molecular Weight

87.08

Formula

C2H5N3O
CAS No.
Appearance

Liquid (Density: 1.146 g/cm3)

Color

Colorless to light yellow

SMILES

[N-]=[N+]=NCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (1148.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.4837 mL 57.4185 mL 114.8369 mL
5 mM 2.2967 mL 11.4837 mL 22.9674 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

COA (241 KB) HNMR (114 KB) GC (203 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 11.4837 mL 57.4185 mL 114.8369 mL 287.0923 mL
5 mM 2.2967 mL 11.4837 mL 22.9674 mL 57.4185 mL
10 mM 1.1484 mL 5.7418 mL 11.4837 mL 28.7092 mL
15 mM 0.7656 mL 3.8279 mL 7.6558 mL 19.1395 mL
20 mM 0.5742 mL 2.8709 mL 5.7418 mL 14.3546 mL
25 mM 0.4593 mL 2.2967 mL 4.5935 mL 11.4837 mL
30 mM 0.3828 mL 1.9139 mL 3.8279 mL 9.5697 mL
40 mM 0.2871 mL 1.4355 mL 2.8709 mL 7.1773 mL
50 mM 0.2297 mL 1.1484 mL 2.2967 mL 5.7418 mL
60 mM 0.1914 mL 0.9570 mL 1.9139 mL 4.7849 mL
80 mM 0.1435 mL 0.7177 mL 1.4355 mL 3.5887 mL
100 mM 0.1148 mL 0.5742 mL 1.1484 mL 2.8709 mL
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Azido-PEG1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azido-PEG11517-05-1PROTAC LinkersInhibitorinhibitorinhibit

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