2. PROTAC
  3. PROTAC Linkers
  4. Azido-PEG2-C6-Cl

Azido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Azido-PEG2-C6-Cl Chemical Structure

Azido-PEG2-C6-Cl Chemical Structure

CAS No. : 2568146-55-2

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25 mg USD 160 In-stock
50 mg USD 260 In-stock
100 mg USD 420 In-stock
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Based on 1 publication(s) in Google Scholar

Azido-PEG2-C6-Cl Related Antibodies

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Description

Azido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azido-PEG2-C6-Cl Related Antibodies
Molecular Weight

249.74

Formula

C10H20ClN3O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

ClCCCCCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1001.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0042 mL 20.0208 mL 40.0416 mL
5 mM 0.8008 mL 4.0042 mL 8.0083 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (239 KB) HNMR (219 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0042 mL 20.0208 mL 40.0416 mL 100.1041 mL
5 mM 0.8008 mL 4.0042 mL 8.0083 mL 20.0208 mL
10 mM 0.4004 mL 2.0021 mL 4.0042 mL 10.0104 mL
15 mM 0.2669 mL 1.3347 mL 2.6694 mL 6.6736 mL
20 mM 0.2002 mL 1.0010 mL 2.0021 mL 5.0052 mL
25 mM 0.1602 mL 0.8008 mL 1.6017 mL 4.0042 mL
30 mM 0.1335 mL 0.6674 mL 1.3347 mL 3.3368 mL
40 mM 0.1001 mL 0.5005 mL 1.0010 mL 2.5026 mL
50 mM 0.0801 mL 0.4004 mL 0.8008 mL 2.0021 mL
60 mM 0.0667 mL 0.3337 mL 0.6674 mL 1.6684 mL
80 mM 0.0501 mL 0.2503 mL 0.5005 mL 1.2513 mL
100 mM 0.0400 mL 0.2002 mL 0.4004 mL 1.0010 mL
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Azido-PEG2-C6-Cl Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azido-PEG2-C6-Cl2568146-55-2PROTAC LinkersInhibitorinhibitorinhibit

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