2. PROTAC
  3. PROTAC Linkers
  4. Azido-PEG5-azide

Azido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Azido-PEG5-azide Chemical Structure

Azido-PEG5-azide Chemical Structure

CAS No. : 356046-26-9

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100 mg USD 95 In-stock
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Based on 1 publication(s) in Google Scholar

Azido-PEG5-azide Related Antibodies

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Description

Azido-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azido-PEG5-azide Related Antibodies
Molecular Weight

332.36

Formula

C12H24N6O5
CAS No.
Appearance

Liquid (Density: 1.13194 g/cm3)

Color

Colorless to light yellow

SMILES

[N-]=[N+]=NCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (300.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0088 mL 15.0439 mL 30.0879 mL
5 mM 0.6018 mL 3.0088 mL 6.0176 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

SDS (251 KB)

COA (239 KB) HNMR (127 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0088 mL 15.0439 mL 30.0879 mL 75.2196 mL
5 mM 0.6018 mL 3.0088 mL 6.0176 mL 15.0439 mL
10 mM 0.3009 mL 1.5044 mL 3.0088 mL 7.5220 mL
15 mM 0.2006 mL 1.0029 mL 2.0059 mL 5.0146 mL
20 mM 0.1504 mL 0.7522 mL 1.5044 mL 3.7610 mL
25 mM 0.1204 mL 0.6018 mL 1.2035 mL 3.0088 mL
30 mM 0.1003 mL 0.5015 mL 1.0029 mL 2.5073 mL
40 mM 0.0752 mL 0.3761 mL 0.7522 mL 1.8805 mL
50 mM 0.0602 mL 0.3009 mL 0.6018 mL 1.5044 mL
60 mM 0.0501 mL 0.2507 mL 0.5015 mL 1.2537 mL
80 mM 0.0376 mL 0.1880 mL 0.3761 mL 0.9402 mL
100 mM 0.0301 mL 0.1504 mL 0.3009 mL 0.7522 mL
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Azido-PEG5-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azido-PEG5-azide356046-26-9PROTAC LinkersInhibitorinhibitorinhibit

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