Azido-PEG5-triethoxysilane

Name: Azido-PEG5-triethoxysilane
Brand: MedChemExpress
SKU: HY-140856
Rating: 4.5 (1 reviews)

Cat. No.: HY-140856 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azido-PEG5-triethoxysilane Chemical Structure

Size	Price	Stock	Quantity
25 mg	USD 145	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 219	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Azido-PEG5-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

538.71

Formula

C₂₂H₄₆N₄O₉Si

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(NCCC[Si](OCC)(OCC)OCC)CCOCCOCCOCCOCCOCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (464.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8563 mL	9.2814 mL	18.5629 mL
5 mM	0.3713 mL	1.8563 mL	3.7126 mL
10 mM	0.1856 mL	0.9281 mL	1.8563 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (240 KB) HNMR (184 KB) MS (58 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8563 mL	9.2814 mL	18.5629 mL	46.4072 mL
	5 mM	0.3713 mL	1.8563 mL	3.7126 mL	9.2814 mL
	10 mM	0.1856 mL	0.9281 mL	1.8563 mL	4.6407 mL
	15 mM	0.1238 mL	0.6188 mL	1.2375 mL	3.0938 mL
	20 mM	0.0928 mL	0.4641 mL	0.9281 mL	2.3204 mL
	25 mM	0.0743 mL	0.3713 mL	0.7425 mL	1.8563 mL
	30 mM	0.0619 mL	0.3094 mL	0.6188 mL	1.5469 mL
	40 mM	0.0464 mL	0.2320 mL	0.4641 mL	1.1602 mL
	50 mM	0.0371 mL	0.1856 mL	0.3713 mL	0.9281 mL
	60 mM	0.0309 mL	0.1547 mL	0.3094 mL	0.7735 mL
	80 mM	0.0232 mL	0.1160 mL	0.2320 mL	0.5801 mL
	100 mM	0.0186 mL	0.0928 mL	0.1856 mL	0.4641 mL