Azidoethyl-SS-ethylamine

Name: Azidoethyl-SS-ethylamine
Brand: MedChemExpress
SKU: HY-140104
Rating: 4.5 (1 reviews)

Cat. No.: HY-140104 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Azidoethyl-SS-ethylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azidoethyl-SS-ethylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azidoethyl-SS-ethylamine Chemical Structure

CAS No. : 1807512-40-8

Size	Price	Stock	Quantity
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Azidoethyl-SS-ethylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Azidoethyl-SS-ethylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

Disulfide Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

178.28

Formula

C₄H₁₀N₄S₂

CAS No.

1807512-40-8

Appearance

Liquid

Color

Light yellow to yellow

SMILES

NCCSSCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1402.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6092 mL	28.0458 mL	56.0915 mL
5 mM	1.1218 mL	5.6092 mL	11.2183 mL
10 mM	0.5609 mL	2.8046 mL	5.6092 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (241 KB) HNMR (234 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.6092 mL	28.0458 mL	56.0915 mL	140.2289 mL
	5 mM	1.1218 mL	5.6092 mL	11.2183 mL	28.0458 mL
	10 mM	0.5609 mL	2.8046 mL	5.6092 mL	14.0229 mL
	15 mM	0.3739 mL	1.8697 mL	3.7394 mL	9.3486 mL
	20 mM	0.2805 mL	1.4023 mL	2.8046 mL	7.0114 mL
	25 mM	0.2244 mL	1.1218 mL	2.2437 mL	5.6092 mL
	30 mM	0.1870 mL	0.9349 mL	1.8697 mL	4.6743 mL
	40 mM	0.1402 mL	0.7011 mL	1.4023 mL	3.5057 mL
	50 mM	0.1122 mL	0.5609 mL	1.1218 mL	2.8046 mL
	60 mM	0.0935 mL	0.4674 mL	0.9349 mL	2.3371 mL
	80 mM	0.0701 mL	0.3506 mL	0.7011 mL	1.7529 mL
	100 mM	0.0561 mL	0.2805 mL	0.5609 mL	1.4023 mL