2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Azidoethyl-SS-ethylamine

Azidoethyl-SS-ethylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azidoethyl-SS-ethylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azidoethyl-SS-ethylamine Chemical Structure

Azidoethyl-SS-ethylamine Chemical Structure

CAS No. : 1807512-40-8

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25 mg USD 160 In-stock
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Based on 1 publication(s) in Google Scholar

Azidoethyl-SS-ethylamine Related Antibodies

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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Description

Azidoethyl-SS-ethylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azidoethyl-SS-ethylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

Disulfide Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azidoethyl-SS-ethylamine Related Antibodies
Molecular Weight

178.28

Formula

C4H10N4S2
CAS No.
Appearance

Liquid

Color

Light yellow to yellow

SMILES

NCCSSCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1402.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6092 mL 28.0458 mL 56.0915 mL
5 mM 1.1218 mL 5.6092 mL 11.2183 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.6092 mL 28.0458 mL 56.0915 mL 140.2289 mL
5 mM 1.1218 mL 5.6092 mL 11.2183 mL 28.0458 mL
10 mM 0.5609 mL 2.8046 mL 5.6092 mL 14.0229 mL
15 mM 0.3739 mL 1.8697 mL 3.7394 mL 9.3486 mL
20 mM 0.2805 mL 1.4023 mL 2.8046 mL 7.0114 mL
25 mM 0.2244 mL 1.1218 mL 2.2437 mL 5.6092 mL
30 mM 0.1870 mL 0.9349 mL 1.8697 mL 4.6743 mL
40 mM 0.1402 mL 0.7011 mL 1.4023 mL 3.5057 mL
50 mM 0.1122 mL 0.5609 mL 1.1218 mL 2.8046 mL
60 mM 0.0935 mL 0.4674 mL 0.9349 mL 2.3371 mL
80 mM 0.0701 mL 0.3506 mL 0.7011 mL 1.7529 mL
100 mM 0.0561 mL 0.2805 mL 0.5609 mL 1.4023 mL
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Azidoethyl-SS-ethylamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azidoethyl-SS-ethylamine1807512-40-8ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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