2. Anti-infection
  3. HBV
  4. BA-53038B

BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B.

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BA-53038B Chemical Structure

BA-53038B Chemical Structure

CAS No. : 2306195-65-1

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Based on 1 publication(s) in Google Scholar

BA-53038B Related Antibodies

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Description

BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B[1].

IC50 & Target

EC 50: 3.32 μM (HBV)[1]
In Vitro

BA-53038B has antiviral activity for HBV with an EC50 value of 3.32 μM[1].
BA-53038B has cytotoxicity with CC50 value of >100 μM[1].
BA-53038B (5 μM; 48 h) induces the capsid/nucleocapsid mobility shift and reduced the amount of hypophosphorylated core protein[1].
BA-53038B (0-20 μM; 2 or 6 days) inhibits HBV nucleocapsid assembly[1].
BA-53038B (5 μM; 2 days) inhibits pgRNA encapsidation and consequentially reduces the amount of DNA-containing capsids and hypophosphorylated core protein[1].
BA-53038B (2 μM; 6 h) modulates HBV capsid assembly by binding to the HAP pocket[1].
BA-53038B has resistant effect with an EC50 value of >10 μM on HBV capsid (HepG2 cells transiently transfected pHBV1.3/core-V124W)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BA-53038B Related Antibodies

Western Blot Analysis[1]

Cell Line: AML12HBV10 cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Reduced the amount of hypophosphorylated core protein and promoted the assembly of empty capsids with slow electrophoresis mobility.

RT-PCR[1]

Cell Line: AML12HBV10 and HepDES19 cells
Concentration: 0-20 μM
Incubation Time: 2 or 6 days
Result: Inhibited HBV replication in both AML12HBV10 and HepDES19 cells.
Molecular Weight

249.74

Formula

C14H16ClNO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=CC(Cl)=C1)C2C3CCCCC32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1001.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0042 mL 20.0208 mL 40.0416 mL
5 mM 0.8008 mL 4.0042 mL 8.0083 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0042 mL 20.0208 mL 40.0416 mL 100.1041 mL
5 mM 0.8008 mL 4.0042 mL 8.0083 mL 20.0208 mL
10 mM 0.4004 mL 2.0021 mL 4.0042 mL 10.0104 mL
15 mM 0.2669 mL 1.3347 mL 2.6694 mL 6.6736 mL
20 mM 0.2002 mL 1.0010 mL 2.0021 mL 5.0052 mL
25 mM 0.1602 mL 0.8008 mL 1.6017 mL 4.0042 mL
30 mM 0.1335 mL 0.6674 mL 1.3347 mL 3.3368 mL
40 mM 0.1001 mL 0.5005 mL 1.0010 mL 2.5026 mL
50 mM 0.0801 mL 0.4004 mL 0.8008 mL 2.0021 mL
60 mM 0.0667 mL 0.3337 mL 0.6674 mL 1.6684 mL
80 mM 0.0501 mL 0.2503 mL 0.5005 mL 1.2513 mL
100 mM 0.0400 mL 0.2002 mL 0.4004 mL 1.0010 mL
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BA-53038B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BA-53038B2306195-65-1HBVHepatitis B virusHBV core protein allosteric modulator (CpAM) HAP pockethepatitis B virus (HBV)chronic hepatitis BantiviralInhibitorinhibitorinhibit

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