Barnidipine  (Synonyms: Mepirodipine; YM-09730-5 Free base)

Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [³H] initrendipine binding sites (K_i = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance^[1][2][3].

Salt form dose:
Barnidipine hydrochloride (53 mg/kg; Feed administration; 3 weeks) reduces the level of platelet-derived growth factor B chain mRNA in spontaneously hypertensive rats, and has a effect on lowering blood pressure^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

491.54

C₂₇H₂₉N₃O₆

104713-75-9

O=C(C1=C(C)NC(C)=C(C(O[C@@H]2CN(CC3=CC=CC=C3)CC2)=O)[C@H]1C4=CC=CC([N+]([O-])=O)=C4)OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8  [Content Brief]

  [2]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.  [Content Brief]

  [3]. Hashimoto M, et al. Treatment with a Ca(2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Am J Nephrol. 1999;19(5):615-21.  [Content Brief]