Barnidipine-d₅  (Synonyms: Mepirodipine-d₅; YM-09730-5-d₅ Free base)

Barnidipine-d₅ is the deuterium-labeled Barnidipine (HY-107322A). Barnidipine-d₅ (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [³H] initrendipine binding sites (K_i=0.21 nmol/l), has selective action against CaA receptors^[1]. Barnidipine-d₅ (Mepirodipine) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action^[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

496.57

C₂₇H₂₄D₅N₃O₆

2771469-19-1

104713-75-9

CC1=C([C@@H](C2=CC([N+]([O-])=O)=CC=C2)C(C(OC)=O)=C(N1)C)C(O[C@@H]3CN(CC3)CC4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.