2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Batracylin

Batracylin  (Synonyms: NSC 320846; BAY-H 2049)

Cat. No.: HY-119892
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Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks.

For research use only. We do not sell to patients.

Batracylin Chemical Structure

Batracylin Chemical Structure

CAS No. : 67199-66-0

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Based on 1 publication(s) in Google Scholar

Batracylin Related Antibodies

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Topoisomerase Topo I Topo II

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Description

Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
46.3 μM
Compound: BAT; Batracylin
Cytotoxicity against human A549 cells after 120 hrs by MTT assay
Cytotoxicity against human A549 cells after 120 hrs by MTT assay
[PMID: 26520842]
HCT-116 IC50
88.7 μM
Compound: BAT; Batracylin
Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay
[PMID: 26520842]
HL-60 IC50
66.6 μM
Compound: BAT; Batracylin
Cytotoxicity against human HL60 cells after 120 hrs by MTT assay
Cytotoxicity against human HL60 cells after 120 hrs by MTT assay
[PMID: 26520842]
HT-29 IC50
64.3 μM
Compound: BAT; Batracylin
Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay
[PMID: 26520842]
L1210 IC50
> 100 μM
Compound: BAT; Batracylin
Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay
Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay
[PMID: 26520842]
LNCaP IC50
90.2 μM
Compound: BAT; Batracylin
Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay
[PMID: 26520842]
MCF7 IC50
> 100 μM
Compound: BAT; Batracylin
Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay
[PMID: 26520842]
NIH3T3 IC50
69.9 μM
Compound: BAT; Batracylin
Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay
[PMID: 26520842]
P388 IC50
> 100 μM
Compound: BAT; Batracylin
Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay
Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay
[PMID: 26520842]
In Vitro

Batracylin (0-300 µM; 6 h) shows cytotoxicity with an IC50 value of 10.02 µM for HT29 cells[1].
Batracylin (100, 300 µM; 3 h) induces protein-linked DNA breaks consistent with topoisomerase targeting[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Batracylin Related Antibodies
Clinical Trial
Molecular Weight

249.27

Formula

C15H11N3O
CAS No.
SMILES

O=C1C2=C(C=CC=C2)C3=NC4=C(CN31)C=C(C=C4)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Batracylin Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Batracylin67199-66-0NSC 320846 BAY-H 2049NSC320846NSC-320846TopoisomeraseHT29 cellsDNA breaksγ-H2AXcytotoxicityInhibitorinhibitorinhibit

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