2. GPCR/G Protein
  3. Guanylate Cyclase
  4. BAY 60-2770

BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.

For research use only. We do not sell to patients.

BAY 60-2770 Chemical Structure

BAY 60-2770 Chemical Structure

CAS No. : 1027642-43-8

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Based on 1 publication(s) in Google Scholar

BAY 60-2770 Related Antibodies

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Description

BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1][2].

In Vivo

BAY 60-2770 (0.1-0.3 mg/Kg; p.o.) attenuates liver fibrosis in two rat models[1].
BAY 60-2770 (1 mg/kg; p.o.; daily from the 10th to the 12th week) results in amelioration of bladder dysfunction in high-fat obese mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Obese mice[2]
Dosage: 1 mg/kg
Administration: p.o.; daily from the 10th to the 12th week
Result: Ameliorates detrusor dysfunction in obese mice.
Molecular Weight

623.63

Formula

C35H33F4NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(CN(CCCCC(O)=O)CCC2=CC(F)=CC=C2OCC3=CC=C(C4=CC=C(C(F)(F)F)C=C4)C=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (26.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6035 mL 8.0176 mL 16.0351 mL
5 mM 0.3207 mL 1.6035 mL 3.2070 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6035 mL 8.0176 mL 16.0351 mL 40.0879 mL
5 mM 0.3207 mL 1.6035 mL 3.2070 mL 8.0176 mL
10 mM 0.1604 mL 0.8018 mL 1.6035 mL 4.0088 mL
15 mM 0.1069 mL 0.5345 mL 1.0690 mL 2.6725 mL
20 mM 0.0802 mL 0.4009 mL 0.8018 mL 2.0044 mL
25 mM 0.0641 mL 0.3207 mL 0.6414 mL 1.6035 mL
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BAY 60-2770 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY 60-27701027642-43-8Guanylate Cyclaseoxide-independentfibroticoralfatbladderdysfunctionInhibitorinhibitorinhibit

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