BCN-PEG1-Val-Cit-PABC-OH

Name: BCN-PEG1-Val-Cit-PABC-OH
Brand: MedChemExpress
SKU: HY-130923
Rating: 4.5 (1 reviews)

Cat. No.: HY-130923 Purity: ≥95.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

BCN-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BCN-PEG1-Val-Cit-PABC-OH is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

BCN-PEG1-Val-Cit-PABC-OH Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

BCN-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. BCN-PEG1-Val-Cit-PABC-OH is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

Protease Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

670.80

Formula

C₃₄H₅₀N₆O₈

Appearance

Solid

SMILES

O=C(NCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CO)C=C1)=O)=O)=O)OCC2[C@]3([H])[C@@]2([H])CCC#CCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (186.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4908 mL	7.4538 mL	14.9076 mL
5 mM	0.2982 mL	1.4908 mL	2.9815 mL
10 mM	0.1491 mL	0.7454 mL	1.4908 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (246 KB) HNMR (308 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4908 mL	7.4538 mL	14.9076 mL	37.2689 mL
	5 mM	0.2982 mL	1.4908 mL	2.9815 mL	7.4538 mL
	10 mM	0.1491 mL	0.7454 mL	1.4908 mL	3.7269 mL
	15 mM	0.0994 mL	0.4969 mL	0.9938 mL	2.4846 mL
	20 mM	0.0745 mL	0.3727 mL	0.7454 mL	1.8634 mL
	25 mM	0.0596 mL	0.2982 mL	0.5963 mL	1.4908 mL
	30 mM	0.0497 mL	0.2485 mL	0.4969 mL	1.2423 mL
	40 mM	0.0373 mL	0.1863 mL	0.3727 mL	0.9317 mL
	50 mM	0.0298 mL	0.1491 mL	0.2982 mL	0.7454 mL
	60 mM	0.0248 mL	0.1242 mL	0.2485 mL	0.6211 mL
	80 mM	0.0186 mL	0.0932 mL	0.1863 mL	0.4659 mL
	100 mM	0.0149 mL	0.0745 mL	0.1491 mL	0.3727 mL