2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. BCR-ABL1-IN-1

BCR-ABL1-IN-1 is a potent, orally active, and specific inhibitor of ABL kinase. BCR-ABL1-IN-1 has potential for elucidating the role of ABL kinases in the brain in non-clinical studies.

For research use only. We do not sell to patients.

BCR-ABL1-IN-1 Chemical Structure

BCR-ABL1-IN-1 Chemical Structure

CAS No. : 1488090-21-6

Size Price Stock Quantity
5 mg USD 120 In-stock
10 mg USD 190 In-stock
25 mg USD 380 In-stock
50 mg USD 600 In-stock
100 mg USD 930 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

BCR-ABL1-IN-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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Description

BCR-ABL1-IN-1 is a potent, orally active, and specific inhibitor of ABL kinase. BCR-ABL1-IN-1 has potential for elucidating the role of ABL kinases in the brain in non-clinical studies[1].

Cellular Effect
Cell Line Type Value Description References
BaF3 GI50
69 nM
Compound: 4
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
[PMID: 35065232]
BaF3 IC50
75 nM
Compound: 4
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
Antiproliferative activity against mouse BaF3 cells expressing BCR-ABL by ATP-luminescence assay
[PMID: 35065232]
Molecular Weight

359.30

Formula

C18H12F3N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN=CC(C2=CC=CN=C2)=C1)NC3=CC=C(C=C3)OC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (487.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7832 mL 13.9159 mL 27.8319 mL
5 mM 0.5566 mL 2.7832 mL 5.5664 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7832 mL 13.9159 mL 27.8319 mL 69.5797 mL
5 mM 0.5566 mL 2.7832 mL 5.5664 mL 13.9159 mL
10 mM 0.2783 mL 1.3916 mL 2.7832 mL 6.9580 mL
15 mM 0.1855 mL 0.9277 mL 1.8555 mL 4.6386 mL
20 mM 0.1392 mL 0.6958 mL 1.3916 mL 3.4790 mL
25 mM 0.1113 mL 0.5566 mL 1.1133 mL 2.7832 mL
30 mM 0.0928 mL 0.4639 mL 0.9277 mL 2.3193 mL
40 mM 0.0696 mL 0.3479 mL 0.6958 mL 1.7395 mL
50 mM 0.0557 mL 0.2783 mL 0.5566 mL 1.3916 mL
60 mM 0.0464 mL 0.2319 mL 0.4639 mL 1.1597 mL
80 mM 0.0348 mL 0.1739 mL 0.3479 mL 0.8697 mL
100 mM 0.0278 mL 0.1392 mL 0.2783 mL 0.6958 mL
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BCR-ABL1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCR-ABL1-IN-11488090-21-6Bcr-AbloralABL kinasebrainnon-clinicalInhibitorinhibitorinhibit

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