2. Apoptosis
  3. Apoptosis
  4. BDM19

BDM19 binds and activates cytosolic BAX dimers, and prompts cell apoptosis either alone or in combination with BCL-2/BCL-XL inhibitor Navitoclax (HY-10087).

For research use only. We do not sell to patients.

BDM19 Chemical Structure

BDM19 Chemical Structure

CAS No. : 500273-31-4

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Based on 1 publication(s) in Google Scholar

BDM19 Related Antibodies

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Description

BDM19 binds and activates cytosolic BAX dimers, and prompts cell apoptosis either alone or in combination with BCL-2/BCL-XL inhibitor Navitoclax (HY-10087)[1].

Molecular Weight

508.31

Formula

C24H17IN2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=CC(/C=C/C2=NC3=CC=C(I)C=C3C(N2C4=CC=C(C(O)=O)C=C4)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9673 mL 9.8365 mL 19.6730 mL
5 mM 0.3935 mL 1.9673 mL 3.9346 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9673 mL 9.8365 mL 19.6730 mL 49.1826 mL
5 mM 0.3935 mL 1.9673 mL 3.9346 mL 9.8365 mL
10 mM 0.1967 mL 0.9837 mL 1.9673 mL 4.9183 mL
15 mM 0.1312 mL 0.6558 mL 1.3115 mL 3.2788 mL
20 mM 0.0984 mL 0.4918 mL 0.9837 mL 2.4591 mL
25 mM 0.0787 mL 0.3935 mL 0.7869 mL 1.9673 mL
30 mM 0.0656 mL 0.3279 mL 0.6558 mL 1.6394 mL
40 mM 0.0492 mL 0.2459 mL 0.4918 mL 1.2296 mL
50 mM 0.0393 mL 0.1967 mL 0.3935 mL 0.9837 mL
60 mM 0.0328 mL 0.1639 mL 0.3279 mL 0.8197 mL
80 mM 0.0246 mL 0.1230 mL 0.2459 mL 0.6148 mL
100 mM 0.0197 mL 0.0984 mL 0.1967 mL 0.4918 mL
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BDM19 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BDM19500273-31-4BDM 19BDM-19ApoptosisHPB-ALLNamalwaSUDHL-5 and SUDHL-16Inhibitorinhibitorinhibit

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