2. Apoptosis Immunology/Inflammation
  3. TNF Receptor CD20
  4. Belimumab

Belimumab  (Synonyms: LymphoStat B)

Cat. No.: HY-P9952 Purity: 99.40%
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Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research.

For research use only. We do not sell to patients.

CAS No. : 356547-88-1

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Description

Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research[1][2][3][4].

Isotype

Human IgG1 lambda
Recommend Isotype Controls
Species

Human
In Vivo

Belimumab (5, 15 or 50 mg/kg, i.v., once every 2 weeks for 13 or 26 weeks) decreases CD20+ B lymphocytes in the peripheral blood in cynomolgus monkeys[3].

Single-Dose Pharmacokinetics of i.v. Belimumab in Cynomolgus Monkeys[3]

Parameters Cmax (μg/mL) AUC0-∞ (day μg/mL) V1 (mL/kg) Vss (mL/kg) CL (mL/day/kg) T1/2,α (day) T1/2,term (day) MRT (day)
5 mg/kg (n=4) 111±2 901±40 45.0±0.7 85.0±2.1 5.6±0.2 0.52±0.13 11.2±0.7 15.4±1.0
50 mg/kg (n=3) 1230±180 8970±320 42.4±5.9 108±14 5.6±0.2 0.44±0.20 14.0±1.8 19.1±2.1
150 mg/kg (n=3) 3778±326 22,693±3990 39.7±3.3 89.8±11.4 6.8±1.3 0.41±0.55 11.5±1.7 13.7±3.5

Pharmacokinetics of Belimumab after 4 times Weekly i.v. Doses in Male and Female Cynomolgus Monkeys[3]
Parameters Cmax (μg/mL) AUC0-∞ (day μg/mL) V1 (mL/kg) Vss (mL/kg) CL (mL/day/kg) T1/2,α (day) T1/2,term (day) MRT (day)
5 mg/kg (n=4) 102±14 717±129 49.7±6.8 126±18 7.2±1.5 0.71±0.26 13.5±1.8 17.8±2.5
50 mg/kg (n=4) 313±38 2365±501 48.4±6.2 108±10 6.5±1.2 1.29±0.61 14.0±3.1 17.0±4.2
150 mg/kg (n=4) 1064±190 9286±1809 48.0±7.8 106±18 5.5±1.1 0.77±0.16 14.6±2.2 19.4±3.5

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy cynomolgus monkeys[3]
Dosage: 5, 15 or 50 mg/kg
Administration: peripheral vein injection, once every 2 weeks for 13 or 26 weeks
Result: Dose-dependently decreased circulating peripheral blood B lymphocytes persisted through at least week 39 and in some monkeys longer despite cessation of treatment at week 26.
Clinical Trial
Molecular Weight

144540.00

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Belimumab]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda
Biological Activity
  • Immobilized BAFF/TNFSF13B Protein, Human (CHO, HY-P7003) can bind Belimumab. The EC50 for this effect is 12 ng/mL.
Purity & Documentation

Purity: 99.40%

SDS (251 KB)

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
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Belimumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belimumab356547-88-1LymphoStat BTNF ReceptorCD20Tumor Necrosis Factor ReceptorTNFRhumanizedIgG1λ monoclonal antibodyB-lymphocyte stimulatorautoimmune diseasesB-lymphocyte malignanciesSLEInhibitorinhibitorinhibit

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