2. Immunology/Inflammation
  3. COX
  4. Benoxaprofen

Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation.

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Benoxaprofen Chemical Structure

Benoxaprofen Chemical Structure

CAS No. : 51234-28-7

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Based on 1 publication(s) in Google Scholar

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Description

Benoxaprofen (LRCL 3794) is a potent and long-acting anti-inflammatory and antipyretic compound. Benoxaprofen is a relatively weak inhibitor of cyclooxygenase in in vitro systems, inhibits lipoxygenase in other systems, and inhibits monocyte migration in some animal models of inflammation[1][2].

Molecular Weight

301.72

Formula

C16H12ClNO3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)C(C)C1=CC=C(OC(C2=CC=C(Cl)C=C2)=N3)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (580.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3143 mL 16.5717 mL 33.1433 mL
5 mM 0.6629 mL 3.3143 mL 6.6287 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.24%

SDS (479 KB)

COA (244 KB) HNMR (238 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3143 mL 16.5717 mL 33.1433 mL 82.8583 mL
5 mM 0.6629 mL 3.3143 mL 6.6287 mL 16.5717 mL
10 mM 0.3314 mL 1.6572 mL 3.3143 mL 8.2858 mL
15 mM 0.2210 mL 1.1048 mL 2.2096 mL 5.5239 mL
20 mM 0.1657 mL 0.8286 mL 1.6572 mL 4.1429 mL
25 mM 0.1326 mL 0.6629 mL 1.3257 mL 3.3143 mL
30 mM 0.1105 mL 0.5524 mL 1.1048 mL 2.7619 mL
40 mM 0.0829 mL 0.4143 mL 0.8286 mL 2.0715 mL
50 mM 0.0663 mL 0.3314 mL 0.6629 mL 1.6572 mL
60 mM 0.0552 mL 0.2762 mL 0.5524 mL 1.3810 mL
80 mM 0.0414 mL 0.2071 mL 0.4143 mL 1.0357 mL
100 mM 0.0331 mL 0.1657 mL 0.3314 mL 0.8286 mL
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Benoxaprofen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benoxaprofen51234-28-7LRCL 3794LRCL3794LRCL-3794COXCyclooxygenaselong-acting anti-inflammatoryantipyretic compoundmonocyte migrationinflammationlipoxygenaseInhibitorinhibitorinhibit

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