Betahistine EP Impurity C  (Synonyms: NSC19005)

Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine^[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)^[2][3].

Betahistine (0-10 μM) inhibits [¹²⁵I]iodoproxyfan binding to membranes of CHO (rH₃₍₄₄₅₎R) and CHO (hH₃₍₄₄₅₎R) cells with IC₅₀ values of 1.9 μM and 3.3 μM, respectively. Lead to K_i values of 1.4 μM and 2.5 μM, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

241.33

C₁₅H₁₉N₃

5452-87-9

Liquid

Light yellow to yellow

CN(CCC1=CC=CC=N1)CCC2=CC=CC=N2

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Murilo B. M. de Mello, et al. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity. J. Braz. Chem. Soc. vol.30 no.7 São Paulo July 2019 Epub July 04, 2019

  [2]. Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.  [Content Brief]

  [3]. Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine^[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)^[2]  [Content Brief]