Bevifimod (Synonyms: PRTX-100)

Cat. No.: HY-P99477: FAQs
Data Sheet Technical Support

Bevifimod (PRTX-100) is a highly purified form of Staphylococcal protein A (SpA). Bevifimod can be used for idiopathic thrombocytopenic purpura (ITP) research.

For research use only. We do not sell to patients.

CAS No. : 2223113-32-2

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Bevifimod Featured Recommendations:

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Bevifimod (PRTX-100) is a highly purified form of Staphylococcal protein A (SpA). Bevifimod can be used for idiopathic thrombocytopenic purpura (ITP) research^[1]^[2].

Species

Staphylococcus aureus

In Vitro

Bevifimod (PRTX-100; 250，25，and 2.5 ng/mL; 48 h) inhibits phagocytosis of W632-opsonized platelets by human monocytes in peripheral blood mononuclear cells (PBMCs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bevifimod (PRTX-100; 2.5-250 μg/kg; i.v.; once every two weeks; for 4 weeks) increases platelet counts to within normal levels within 1-2 weeks and none of the mice died^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	SCID mice bearing immune thrombocytopenia (ITP)^[2]
Dosage:	2.5 μg/kg, 25 μg/kg, 250 μg/kg
Administration:	i.v.; once every two weeks; for 4 weeks
Result:	Raised platelet counts in a well-established murine model of ITP.

Clinical Trial

CAS No.

2223113-32-2

SMILES

[Bevifimod]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

staphylococcal protein A (SpA)

Purity & Documentation

Inhibitory Antibodies User Guide (602 KB)

References

[1]. ChrisYatkoBS, et al. PRTX-100 Inhibits Platelet Phagocytosis In Vitro. Blood (2006) 108 (11): 1081.

[2]. John W. Semple, et al. Successful Treatment of Thrombocytopenia with Staphylococcal Protein A (PRTX-100) in a Murine Model of Immune Thrombocytopenia (ITP). Blood (2015) 126 (23): 1045.

Bevifimod Related Classifications

Inflammation/Immunology Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bevifimod2223113-32-2PRTX-100PRTX100PRTX 100Othersidiopathic thrombocytopenic purpuraStaphylococcal protein AInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *