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  4. Bevifimod

Bevifimod (PRTX-100) is a highly purified form of Staphylococcal protein A (SpA). Bevifimod can be used for idiopathic thrombocytopenic purpura (ITP) research.

For research use only. We do not sell to patients.

CAS No. : 2223113-32-2

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Bevifimod Related Antibodies

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Description

Bevifimod (PRTX-100) is a highly purified form of Staphylococcal protein A (SpA). Bevifimod can be used for idiopathic thrombocytopenic purpura (ITP) research[1][2].

Species

Staphylococcus aureus
In Vitro

Bevifimod (PRTX-100; 250, 25, and 2.5 ng/mL; 48 hours) inhibits the phagocytosis of W632 opsonized platelets by human monocytes in peripheral blood mononuclear cells (PBMCs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bevifimod Related Antibodies
In Vivo

Bevifimod（PRTX-100；2.5-250 μg/kg；i.v.；每两周一次；持续 4 周）在 1-2 周内将血小板计数增加到正常水平，并且没有小鼠死亡[2]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice bearing immune thrombocytopenia (ITP)[2]
Dosage: 2.5 μg/kg, 25 μg/kg, 250 μg/kg
Administration: i.v.; once every two weeks; for 4 weeks
Result: Raised platelet counts in a well-established murine model of ITP.
Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT00517855Protalex, Inc.
Healthy Volunteers
June 2007Phase 1
NCT00571467Protalex, Inc.
Idiopathic Thrombocytopenic Purpura (ITP)
December 2007Phase 1
NCT02566603Protalex, Inc.
Immune Thrombocytopenia
November 2015Phase 1|Phase 2
CAS No.
SMILES

[Bevifimod]
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Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • staphylococcal protein A (SpA)
Purity & Documentation
References
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Bevifimod Related Classifications

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Keywords:

Bevifimod2223113-32-2PRTX-100PRTX100PRTX 100Othersidiopathic thrombocytopenic purpuraStaphylococcal protein AInhibitorinhibitorinhibit

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