Bezafibrate-d₆

Name: Bezafibrate-d 6
Brand: MedChemExpress
SKU: HY-B0637S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0637S Purity: ≥98.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Bezafibrate-d₆ is the deuterium labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.

For research use only. We do not sell to patients.

Bezafibrate-d<sub>6</sub> Chemical Structure

Bezafibrate-d₆ Chemical Structure

CAS No. : 1219802-74-0

Size	Stock	Quantity
1 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 2-4 weeks 2-4 weeks 2-4 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

Synthetic products have potential research and development risk.

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Bezafibrate-d₆:

Bezafibrate In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

View All Isoforms

PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.86

Formula

C₁₉H₁₄D₆ClNO₄

CAS No.

1219802-74-0

Unlabeled CAS

41859-67-0

Appearance

Solid

Color

White to light yellow

SMILES

OC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])OC(C=C1)=CC=C1CCNC(C2=CC=C(C=C2)Cl)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 30 mg/mL (81.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 30 mg/mL (81.55 mM)

Ethanol : ≥ 3 mg/mL (8.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7184 mL	13.5921 mL	27.1843 mL
5 mM	0.5437 mL	2.7184 mL	5.4369 mL
10 mM	0.2718 mL	1.3592 mL	2.7184 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. [Content Brief]

[3]. Usui-Ouchi A, et al. The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cell [Content Brief]

[4]. Franko A, et al. Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice. Mol Metab. 2017 Jan 6;6(3):256-266. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO / DMF	1 mM	2.7184 mL	13.5921 mL	27.1843 mL	67.9606 mL
Ethanol / DMSO / DMF	5 mM	0.5437 mL	2.7184 mL	5.4369 mL	13.5921 mL
DMSO / DMF	10 mM	0.2718 mL	1.3592 mL	2.7184 mL	6.7961 mL
	15 mM	0.1812 mL	0.9061 mL	1.8123 mL	4.5307 mL
	20 mM	0.1359 mL	0.6796 mL	1.3592 mL	3.3980 mL
	25 mM	0.1087 mL	0.5437 mL	1.0874 mL	2.7184 mL
	30 mM	0.0906 mL	0.4531 mL	0.9061 mL	2.2654 mL
	40 mM	0.0680 mL	0.3398 mL	0.6796 mL	1.6990 mL
	50 mM	0.0544 mL	0.2718 mL	0.5437 mL	1.3592 mL
	60 mM	0.0453 mL	0.2265 mL	0.4531 mL	1.1327 mL
	80 mM	0.0340 mL	0.1699 mL	0.3398 mL	0.8495 mL