2. Apoptosis
  3. Bcl-2 Family
  4. Bim-IN-1

Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity.

For research use only. We do not sell to patients.

Bim-IN-1 Chemical Structure

Bim-IN-1 Chemical Structure

CAS No. : 2909483-36-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 286 In-stock
Solution
10 mM * 1 mL in DMSO USD 286 In-stock
Solid
5 mg USD 260 In-stock
10 mg USD 380 In-stock
25 mg USD 800 In-stock
50 mg USD 1280 In-stock
100 mg USD 2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Bim-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Bcl-2 Family Isoform Specific Products:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • Biological Activity

  • Purity & Documentation

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Description

Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity[1].

IC50 & Target

Bim

 

In Vitro

Bim-IN-1 (compound 63, mouse embryonic fibroblasts; 0, 25, 50 μM; 72 hours) demonstrates strong reduction of Bim expression levels at a low micromolar level with low toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bim-IN-1 Related Antibodies
Molecular Weight

416.34

Formula

C19H20Cl2FNO2S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

FC1=CC(C2N(S(=O)(CC3=CC=C(Cl)C=C3Cl)=O)CCCCC2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (480.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4019 mL 12.0094 mL 24.0188 mL
5 mM 0.4804 mL 2.4019 mL 4.8038 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4019 mL 12.0094 mL 24.0188 mL 60.0471 mL
5 mM 0.4804 mL 2.4019 mL 4.8038 mL 12.0094 mL
10 mM 0.2402 mL 1.2009 mL 2.4019 mL 6.0047 mL
15 mM 0.1601 mL 0.8006 mL 1.6013 mL 4.0031 mL
20 mM 0.1201 mL 0.6005 mL 1.2009 mL 3.0024 mL
25 mM 0.0961 mL 0.4804 mL 0.9608 mL 2.4019 mL
30 mM 0.0801 mL 0.4003 mL 0.8006 mL 2.0016 mL
40 mM 0.0600 mL 0.3002 mL 0.6005 mL 1.5012 mL
50 mM 0.0480 mL 0.2402 mL 0.4804 mL 1.2009 mL
60 mM 0.0400 mL 0.2002 mL 0.4003 mL 1.0008 mL
80 mM 0.0300 mL 0.1501 mL 0.3002 mL 0.7506 mL
100 mM 0.0240 mL 0.1201 mL 0.2402 mL 0.6005 mL
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Bim-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bim-IN-12909483-36-7Bcl-2 FamilyMouse embryonic fibroblasts (MEFs)lower toxicityprotein kinase AInhibitorinhibitorinhibit

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