2. Immunology/Inflammation
  3. Interleukin Related
  4. Bimekizumab

Bimekizumab  (Synonyms: Anti-Human IL17A/IL-17F Recombinant Antibody)

Cat. No.: HY-P99280 Purity: ≥95.0%
SDS
COA
Technical Support

Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) is a humanised monoclonal antibody, can selectively neutralises IL-17A and IL-17F. Both of them are pro-osteogenic with respect to human periosteum-derived cell (hPDC) differentiation. Thus Bimekizumab blocks the inflammation-driven osteogenic differentiation.

For research use only. We do not sell to patients.

CAS No. : 1418205-77-2

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Based on 1 publication(s) in Google Scholar

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Bimekizumab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Bimekizumab

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • Biological Activity

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  • Customer Review

Description

Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) is a humanised monoclonal antibody, can selectively neutralises IL-17A and IL-17F. Both of them are pro-osteogenic with respect to human periosteum-derived cell (hPDC) differentiation. Thus Bimekizumab blocks the inflammation-driven osteogenic differentiation[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target[1]

IL-17A

 

IL-17F

 

In Vitro

Bimekizumab (10 μg/mL; 1 h) results dual neutralisation of IL-17A and IL-17F, leads to osteocommitment of hPDCs by AS serum is suppressed[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bimekizumab Related Antibodies
Clinical Trial
Molecular Weight

147240.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Bimekizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized IL-17A (136a.a)-17F Heterodimer Protein, Human can bind Bimekizumab. The EC50 for this effect is 16.18 ng/mL.
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Bimekizumab Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bimekizumab1418205-77-2Anti-Human IL17A/IL-17F Recombinant AntibodyInterleukin RelatedILankylosing spondylitiscytokinesinflammationT cellsInhibitorinhibitorinhibit

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