2. Anti-infection
  3. Bacterial
  4. Bio-AMS TFA

Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. Bio-AMS (TFA) possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis.

For research use only. We do not sell to patients.

Bio-AMS TFA Chemical Structure

Bio-AMS TFA Chemical Structure

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1 mg USD 185 In-stock
5 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Bio-AMS TFA:

Bio-AMS TFA Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. Bio-AMS (TFA) possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis[1].

IC50 & Target

Biotin protein ligase[1]
In Vitro

Bio-AMS possesses excellent antitubercular activity against Mtb H37Rv and MDR/XDR-TB strains with MICs ranging from 0.16 to 0.625 μM and is not affected by changes to the primary carbon source[1].
Bio-AMS (2.5, 5 and 10 μM; 24 h) inhibits growth of Mtb in a concentration-dependent manner in Mtb-infected mouse macrophages; shows no signs of mitochondrial toxicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bio-AMS TFA Related Antibodies
Molecular Weight

685.65

Formula

C22H30F3N9O9S2
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@@H]1O)[C@@H](O[C@@H]1CNS(NC(CCCC[C@H]2[C@](NC3=O)([H])[C@](N3)([H])CS2)=O)(=O)=O)N4C5=NC=NC(N)=C5N=C4.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Bio-AMS TFA Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bio-AMSBacterialbiotin protein ligaseMycobacterium tuberculosisMtbInhibitorinhibitorinhibit

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Product Name:
Bio-AMS TFA
Cat. No.:
HY-115448A
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