2. Anti-infection
  3. Bacterial
  4. Bio-AMS

Bio-AMS is a potent bacterial biotin protein ligase inhibitor. Bio-AMS possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis.

For research use only. We do not sell to patients.

Bio-AMS Chemical Structure

Bio-AMS Chemical Structure

CAS No. : 1393881-52-1

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5 mg USD 550 In-stock
10 mg USD 900 In-stock
25 mg USD 1900 In-stock
50 mg USD 3150 In-stock
100 mg USD 5000 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Bio-AMS:

Bio-AMS Related Antibodies

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  • Purity & Documentation

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Description

Bio-AMS is a potent bacterial biotin protein ligase inhibitor. Bio-AMS possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis[1][2].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
> 100 μM
Compound: 14, Bio-AMS
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26299766]
Molecular Weight

571.63

Formula

C20H29N9O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@@H]1O)[C@@H](O[C@@H]1CNS(NC(CCCC[C@H]2[C@](NC3=O)([H])[C@](N3)([H])CS2)=O)(=O)=O)N4C5=NC=NC(N)=C5N=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (174.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7494 mL 8.7469 mL 17.4938 mL
5 mM 0.3499 mL 1.7494 mL 3.4988 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7494 mL 8.7469 mL 17.4938 mL 43.7346 mL
5 mM 0.3499 mL 1.7494 mL 3.4988 mL 8.7469 mL
10 mM 0.1749 mL 0.8747 mL 1.7494 mL 4.3735 mL
15 mM 0.1166 mL 0.5831 mL 1.1663 mL 2.9156 mL
20 mM 0.0875 mL 0.4373 mL 0.8747 mL 2.1867 mL
25 mM 0.0700 mL 0.3499 mL 0.6998 mL 1.7494 mL
30 mM 0.0583 mL 0.2916 mL 0.5831 mL 1.4578 mL
40 mM 0.0437 mL 0.2187 mL 0.4373 mL 1.0934 mL
50 mM 0.0350 mL 0.1749 mL 0.3499 mL 0.8747 mL
60 mM 0.0292 mL 0.1458 mL 0.2916 mL 0.7289 mL
80 mM 0.0219 mL 0.1093 mL 0.2187 mL 0.5467 mL
100 mM 0.0175 mL 0.0875 mL 0.1749 mL 0.4373 mL
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Bio-AMS Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bio-AMS1393881-52-1Bacterialbiotin protein ligaseMycobacterium tuberculosisMtbInhibitorinhibitorinhibit

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