Angiotensin type 1 receptor (AT1)

Definition:

Angiotensin type 1 receptor (AT1R) is a functional target for non-HLA allo- and autoantibodies (AT(1)R-Abs) comprising of IgG1 and IgG3 subclasses. AT1R is an important pharmacological target in the treatment of cardiovascular disorders, such as hypertension, diabetic nephropathy, cardiac hypertrophy, arrhythmia and failure.

References:

[1]. Aplin M, et al. Molecular determinants of angiotensin II type 1 receptor functional selectivity. J Mol Cell Cardiol. 2009 Jan;46(1):15-24. [Content Brief]

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