AP-4 complex subunit mu-1

Definition:

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity).

References:

[1]. J Hirst, et al. Characterization of a fourth adaptor-related protein complex. Mol Biol Cell. 1999 Aug;10(8):2787-802. [Content Brief]

[2]. E C Dell'Angelica, et al. AP-4, a novel protein complex related to clathrin adaptors. J Biol Chem. 1999 Mar 12;274(11):7278-85. [Content Brief]

[3]. R C Aguilar, et al. Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4. J Biol Chem. 2001 Apr 20;276(16):13145-52. [Content Brief]

[4]. Patricia V Burgos, et al. Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell. 2010 Mar 16;18(3):425-36. [Content Brief]

[5]. Thomas Simmen, et al. AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells. Nat Cell Biol. 2002 Feb;4(2):154-9. [Content Brief]

[6]. M Hashim Raza, et al. Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering. Am J Hum Genet. 2015 Nov 5;97(5):715-25. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.