Apolipoprotein C-I

Definition:

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

References:

[1]. Marit Westerterp, et al. Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification. J Lipid Res. 2007 Jun;48(6):1353-61. [Content Brief]

[2]. Donald L Puppione, et al. Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes. Comp Biochem Physiol Part D Genomics Proteomics. 2014 Sep;11:45-8. [Content Brief]

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