AT-rich interactive domain-containing protein 2

Definition:

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes.

References:

[1]. Ghia Euskirchen, et al. SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions. J Biol Chem. 2012 Sep 7;287(37):30897-905. [Content Brief]

[2]. Xiaomin Zhang, et al. Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation. Biochem Biophys Res Commun. 2006 Aug 4;346(3):794-801. [Content Brief]

[3]. Cigall Kadoch, et al. Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics. Sci Adv. 2015 Jun 12;1(5):e1500447. [Content Brief]

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