ATP-binding cassette sub-family B member 6

Definition:

ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen. May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress. May also play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils. In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin. In addition may play a role in the transition metal homeostasis (By similarity).

References:

[1]. Chunyu Wang, et al. Cryo-electron microscopy structure of human ABCB6 transporter. Protein Sci. 2020 Dec;29(12):2363-2374. [Content Brief]

[2]. Partha C Krishnamurthy, et al. Identification of a mammalian mitochondrial porphyrin transporter. Nature. 2006 Oct 5;443(7111):586-9. [Content Brief]

[3]. Kentaro Minami, et al. Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine. Anticancer Res. 2014 Sep;34(9):4767-73. [Content Brief]

[4]. Yu Fukuda, et al. The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6. Nat Commun. 2016 Aug 10;7:12353. [Content Brief]

[5]. N Mitsuhashi, et al. MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. J Biol Chem. 2000 Jun 9;275(23):17536-40. [Content Brief]

[6]. Jill K Paterson, et al. Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane. Biochemistry. 2007 Aug 21;46(33):9443-52. [Content Brief]

[7]. Hemantkumar Chavan, et al. The ATP-binding cassette transporter ABCB6 is induced by arsenic and protects against arsenic cytotoxicity. Toxicol Sci. 2011 Apr;120(2):519-28. [Content Brief]

[8]. Zsófia Rakvács, et al. The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification. Cell Mol Life Sci. 2019 Oct;76(20):4131-4144. [Content Brief]

[9]. Ptissam Bergam, et al. ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation. J Mol Biol. 2018 Oct 12;430(20):3802-3818. [Content Brief]

[10]. Hemantkumar Chavan, et al. Efficient purification and reconstitution of ATP binding cassette transporter B6 (ABCB6) for functional and structural studies. J Biol Chem. 2013 Aug 2;288(31):22658-69. [Content Brief]

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