Cell division cycle-associated protein 7

Definition:

Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator.

References:

[1]. J E Prescott, et al. A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation. J Biol Chem. 2001 Dec 21;276(51):48276-84. [Content Brief]

[2]. R Montgomery Gill, et al. The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. Mol Cell Biol. 2013 Feb;33(3):498-513. [Content Brief]

[3]. Rebecca C Osthus, et al. The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. Cancer Res. 2005 Jul 1;65(13):5620-7. [Content Brief]

[4]. Yuya Goto, et al. JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity. Biochim Biophys Acta. 2006 Jan-Feb;1759(1-2):60-8. [Content Brief]

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