Cyclin-dependent kinase 14

Definition:

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

References:

[1]. Gary Davidson, et al. Cell cycle control of wnt receptor activation. Dev Cell. 2009 Dec;17(6):788-99. [Content Brief]

[2]. Mei Jiang, et al. Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1. FEBS Lett. 2009 Jul 7;583(13):2171-8. [Content Brief]

[3]. Fang Shu, et al. Functional characterization of human PFTK1 as a cyclin-dependent kinase. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9248-53. [Content Brief]

[4]. Xiaoqing Tang, et al. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2087-92. [Content Brief]

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