PPP2R1A-PPP2R2A-interacting phosphatase regulator 1

Definition:

Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint.

References:

[1]. Li Fan, et al. FAM122A, a new endogenous inhibitor of protein phosphatase 2A. Oncotarget. 2016 Sep 27;7(39):63887-63900. [Content Brief]

[2]. Feng Li, et al. CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. Mol Cell. 2020 Nov 5;80(3):410-422.e6. [Content Brief]

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