Sorbin and SH3 domain-containing protein 2

Definition:

Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.

References:

[1]. Philippe Soubeyran, et al. Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl. Biochem J. 2003 Feb 15;370(Pt 1):29-34. [Content Brief]

[2]. David Taieb, et al. ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity. Cancer Res. 2008 Jun 15;68(12):4588-96. [Content Brief]

[3]. B Wang, et al. ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. J Biol Chem. 1997 Jul 11;272(28):17542-50. [Content Brief]

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