Thromboxane-A synthase

Definition:

Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Cleaves also PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.

References:

[1]. C Yokoyama, et al. Expression of human thromboxane synthase using a baculovirus system. FEBS Lett. 1993 Feb 22;318(1):91-4. [Content Brief]

[2]. L H Wang, et al. Substrate binding is the rate-limiting step in thromboxane synthase catalysis. J Biol Chem. 2001 May 4;276(18):14737-43. [Content Brief]

[3]. Chung-Ying K Chen, et al. Functional analysis of human thromboxane synthase polymorphic variants. Pharmacogenet Genomics. 2012 Sep;22(9):653-8. [Content Brief]

[4]. P Y Hsu, et al. Expression, purification, and spectroscopic characterization of human thromboxane synthase. J Biol Chem. 1999 Jan 8;274(2):762-9. [Content Brief]

[5]. P Y Hsu, et al. Identification of thromboxane synthase amino acid residues involved in heme-propionate binding. Arch Biochem Biophys. 2000 Nov 1;383(1):119-27. [Content Brief]

[6]. Takehiko Matsunobu, et al. Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. J Lipid Res. 2013 Nov;54(11):2979-87. [Content Brief]

[7]. Hui-Chun Yeh, et al. Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. Arch Biochem Biophys. 2007 May 15;461(2):159-68. [Content Brief]

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