Tumor necrosis factor receptor superfamily member 3

Definition:

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

References:

[1]. P D Crowe, et al. A lymphotoxin-beta-specific receptor. Science. 1994 Apr 29;264(5159):707-10. [Content Brief]

[2]. I A Rooney, et al. The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. J Biol Chem. 2000 May 12;275(19):14307-15. [Content Brief]

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