Biotin-C5-NHS Ester

Cat. No.: HY-135915 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-C5-NHS Ester Chemical Structure

CAS No. : 72040-63-2

Size	Price	Stock	Quantity
100 mg	USD 52	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 63	In-stock	Estimated Time of Arrival: December 31
1 g	USD 251	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

454.54

Formula

C₂₀H₃₀N₄O₆S

CAS No.

72040-63-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(CCC1=O)=O)CCCCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (220.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2000 mL	11.0001 mL	22.0003 mL
5 mM	0.4400 mL	2.2000 mL	4.4001 mL
10 mM	0.2200 mL	1.1000 mL	2.2000 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (134 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2000 mL	11.0001 mL	22.0003 mL	55.0007 mL
	5 mM	0.4400 mL	2.2000 mL	4.4001 mL	11.0001 mL
	10 mM	0.2200 mL	1.1000 mL	2.2000 mL	5.5001 mL
	15 mM	0.1467 mL	0.7333 mL	1.4667 mL	3.6667 mL
	20 mM	0.1100 mL	0.5500 mL	1.1000 mL	2.7500 mL
	25 mM	0.0880 mL	0.4400 mL	0.8800 mL	2.2000 mL
	30 mM	0.0733 mL	0.3667 mL	0.7333 mL	1.8334 mL
	40 mM	0.0550 mL	0.2750 mL	0.5500 mL	1.3750 mL
	50 mM	0.0440 mL	0.2200 mL	0.4400 mL	1.1000 mL
	60 mM	0.0367 mL	0.1833 mL	0.3667 mL	0.9167 mL
	80 mM	0.0275 mL	0.1375 mL	0.2750 mL	0.6875 mL
	100 mM	0.0220 mL	0.1100 mL	0.2200 mL	0.5500 mL