Biotin-PEG-Biotin

Name: Biotin-PEG-Biotin
Brand: MedChemExpress
SKU: HY-140656A
Rating: 4.5 (1 reviews)

Cat. No.: HY-140656A: FAQs
Data Sheet SDS Handling Instructions Technical Support

Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG-Biotin Chemical Structure

CAS No. : 194920-55-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

600.79

Formula

C₂₆H₄₄N₆O₆S₂

CAS No.

194920-55-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCCOCCOCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O)CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 175 mg/mL (291.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6645 mL	8.3224 mL	16.6448 mL
5 mM	0.3329 mL	1.6645 mL	3.3290 mL
10 mM	0.1664 mL	0.8322 mL	1.6645 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (267 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6645 mL	8.3224 mL	16.6448 mL	41.6119 mL
	5 mM	0.3329 mL	1.6645 mL	3.3290 mL	8.3224 mL
	10 mM	0.1664 mL	0.8322 mL	1.6645 mL	4.1612 mL
	15 mM	0.1110 mL	0.5548 mL	1.1097 mL	2.7741 mL
	20 mM	0.0832 mL	0.4161 mL	0.8322 mL	2.0806 mL
	25 mM	0.0666 mL	0.3329 mL	0.6658 mL	1.6645 mL
	30 mM	0.0555 mL	0.2774 mL	0.5548 mL	1.3871 mL
	40 mM	0.0416 mL	0.2081 mL	0.4161 mL	1.0403 mL
	50 mM	0.0333 mL	0.1664 mL	0.3329 mL	0.8322 mL
	60 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.6935 mL
	80 mM	0.0208 mL	0.1040 mL	0.2081 mL	0.5201 mL
	100 mM	0.0166 mL	0.0832 mL	0.1664 mL	0.4161 mL