2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG2-OH

Biotin-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG2-OH Chemical Structure

Biotin-PEG2-OH Chemical Structure

CAS No. : 717119-80-7

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25 mg USD 45 In-stock
50 mg USD 70 In-stock
100 mg USD 110 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Biotin-PEG2-OH Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Biotin-PEG2-OH

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Biotin-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG2-OH Related Antibodies
Molecular Weight

331.43

Formula

C14H25N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCOCCO)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (301.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0172 mL 15.0861 mL 30.1723 mL
5 mM 0.6034 mL 3.0172 mL 6.0345 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (244 KB) HNMR (138 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0172 mL 15.0861 mL 30.1723 mL 75.4307 mL
5 mM 0.6034 mL 3.0172 mL 6.0345 mL 15.0861 mL
10 mM 0.3017 mL 1.5086 mL 3.0172 mL 7.5431 mL
15 mM 0.2011 mL 1.0057 mL 2.0115 mL 5.0287 mL
20 mM 0.1509 mL 0.7543 mL 1.5086 mL 3.7715 mL
25 mM 0.1207 mL 0.6034 mL 1.2069 mL 3.0172 mL
30 mM 0.1006 mL 0.5029 mL 1.0057 mL 2.5144 mL
40 mM 0.0754 mL 0.3772 mL 0.7543 mL 1.8858 mL
50 mM 0.0603 mL 0.3017 mL 0.6034 mL 1.5086 mL
60 mM 0.0503 mL 0.2514 mL 0.5029 mL 1.2572 mL
80 mM 0.0377 mL 0.1886 mL 0.3772 mL 0.9429 mL
100 mM 0.0302 mL 0.1509 mL 0.3017 mL 0.7543 mL
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Biotin-PEG2-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG2-OH717119-80-7PROTAC LinkersInhibitorinhibitorinhibit

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