2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG4-acid

Biotin-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

For research use only. We do not sell to patients.

Biotin-PEG4-acid Chemical Structure

Biotin-PEG4-acid Chemical Structure

CAS No. : 721431-18-1

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Based on 1 publication(s) in Google Scholar

Biotin-PEG4-acid Related Antibodies

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Description

Biotin-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG4-acid Related Antibodies
Molecular Weight

491.60

Formula

C21H37N3O8S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (203.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0342 mL 10.1709 mL 20.3417 mL
5 mM 0.4068 mL 2.0342 mL 4.0683 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (241 KB) HNMR (134 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0342 mL 10.1709 mL 20.3417 mL 50.8544 mL
5 mM 0.4068 mL 2.0342 mL 4.0683 mL 10.1709 mL
10 mM 0.2034 mL 1.0171 mL 2.0342 mL 5.0854 mL
15 mM 0.1356 mL 0.6781 mL 1.3561 mL 3.3903 mL
20 mM 0.1017 mL 0.5085 mL 1.0171 mL 2.5427 mL
25 mM 0.0814 mL 0.4068 mL 0.8137 mL 2.0342 mL
30 mM 0.0678 mL 0.3390 mL 0.6781 mL 1.6951 mL
40 mM 0.0509 mL 0.2543 mL 0.5085 mL 1.2714 mL
50 mM 0.0407 mL 0.2034 mL 0.4068 mL 1.0171 mL
60 mM 0.0339 mL 0.1695 mL 0.3390 mL 0.8476 mL
80 mM 0.0254 mL 0.1271 mL 0.2543 mL 0.6357 mL
100 mM 0.0203 mL 0.1017 mL 0.2034 mL 0.5085 mL
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Biotin-PEG4-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG4-acid721431-18-1PROTAC LinkersProtaclinkerpegcancerInhibitorinhibitorinhibit

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