2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG5-azide

Biotin-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Biotin-PEG5-azide Chemical Structure

Biotin-PEG5-azide Chemical Structure

CAS No. : 1163732-89-5

Size Price Stock Quantity
50 mg USD 68 In-stock
100 mg USD 103 In-stock
250 mg USD 166 In-stock
500 mg USD 251 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Biotin-PEG5-azide Related Antibodies

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Description

Biotin-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG5-azide Related Antibodies
Molecular Weight

532.65

Formula

C22H40N6O7S
CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

O=C(NCCOCCOCCOCCOCCOCCN=[N+]=[N-])CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (187.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8774 mL 9.3870 mL 18.7741 mL
5 mM 0.3755 mL 1.8774 mL 3.7548 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8774 mL 9.3870 mL 18.7741 mL 46.9351 mL
5 mM 0.3755 mL 1.8774 mL 3.7548 mL 9.3870 mL
10 mM 0.1877 mL 0.9387 mL 1.8774 mL 4.6935 mL
15 mM 0.1252 mL 0.6258 mL 1.2516 mL 3.1290 mL
20 mM 0.0939 mL 0.4694 mL 0.9387 mL 2.3468 mL
25 mM 0.0751 mL 0.3755 mL 0.7510 mL 1.8774 mL
30 mM 0.0626 mL 0.3129 mL 0.6258 mL 1.5645 mL
40 mM 0.0469 mL 0.2347 mL 0.4694 mL 1.1734 mL
50 mM 0.0375 mL 0.1877 mL 0.3755 mL 0.9387 mL
60 mM 0.0313 mL 0.1565 mL 0.3129 mL 0.7823 mL
80 mM 0.0235 mL 0.1173 mL 0.2347 mL 0.5867 mL
100 mM 0.0188 mL 0.0939 mL 0.1877 mL 0.4694 mL
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Biotin-PEG5-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG5-azide1163732-89-5PROTAC LinkersProtaclinkerpegcancerInhibitorinhibitorinhibit

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