2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG8-acid

Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG8-acid Chemical Structure

Biotin-PEG8-acid Chemical Structure

CAS No. : 2143964-62-7

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100 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

Biotin-PEG8-acid Related Antibodies

Top Publications Citing Use of Products

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Description

Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG8-acid Related Antibodies
Molecular Weight

667.81

Formula

C29H53N3O12S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (187.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4974 mL 7.4872 mL 14.9743 mL
5 mM 0.2995 mL 1.4974 mL 2.9949 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4974 mL 7.4872 mL 14.9743 mL 37.4358 mL
5 mM 0.2995 mL 1.4974 mL 2.9949 mL 7.4872 mL
10 mM 0.1497 mL 0.7487 mL 1.4974 mL 3.7436 mL
15 mM 0.0998 mL 0.4991 mL 0.9983 mL 2.4957 mL
20 mM 0.0749 mL 0.3744 mL 0.7487 mL 1.8718 mL
25 mM 0.0599 mL 0.2995 mL 0.5990 mL 1.4974 mL
30 mM 0.0499 mL 0.2496 mL 0.4991 mL 1.2479 mL
40 mM 0.0374 mL 0.1872 mL 0.3744 mL 0.9359 mL
50 mM 0.0299 mL 0.1497 mL 0.2995 mL 0.7487 mL
60 mM 0.0250 mL 0.1248 mL 0.2496 mL 0.6239 mL
80 mM 0.0187 mL 0.0936 mL 0.1872 mL 0.4679 mL
100 mM 0.0150 mL 0.0749 mL 0.1497 mL 0.3744 mL
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Biotin-PEG8-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG8-acid2143964-62-7PROTAC LinkersInhibitorinhibitorinhibit

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