Biotin-PEG8-alcohol

Cat. No.: HY-140894 Purity: 99.30%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Biotin-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG8-alcohol Chemical Structure

CAS No. : 2182601-20-1

Size	Price	Stock	Quantity
50 mg	USD 86	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Biotin-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

595.75

Formula

C₂₆H₄₉N₃O₁₀S

CAS No.

2182601-20-1

Appearance

Oil

Color

Colorless to off-white

SMILES

O=C(NCCOCCOCCOCCOCCOCCOCCOCCO)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (419.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6786 mL	8.3928 mL	16.7856 mL
5 mM	0.3357 mL	1.6786 mL	3.3571 mL
10 mM	0.1679 mL	0.8393 mL	1.6786 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.30%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (240 KB) HNMR (291 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6786 mL	8.3928 mL	16.7856 mL	41.9639 mL
	5 mM	0.3357 mL	1.6786 mL	3.3571 mL	8.3928 mL
	10 mM	0.1679 mL	0.8393 mL	1.6786 mL	4.1964 mL
	15 mM	0.1119 mL	0.5595 mL	1.1190 mL	2.7976 mL
	20 mM	0.0839 mL	0.4196 mL	0.8393 mL	2.0982 mL
	25 mM	0.0671 mL	0.3357 mL	0.6714 mL	1.6786 mL
	30 mM	0.0560 mL	0.2798 mL	0.5595 mL	1.3988 mL
	40 mM	0.0420 mL	0.2098 mL	0.4196 mL	1.0491 mL
	50 mM	0.0336 mL	0.1679 mL	0.3357 mL	0.8393 mL
	60 mM	0.0280 mL	0.1399 mL	0.2798 mL	0.6994 mL
	80 mM	0.0210 mL	0.1049 mL	0.2098 mL	0.5245 mL
	100 mM	0.0168 mL	0.0839 mL	0.1679 mL	0.4196 mL