2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG8-alcohol

Biotin-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Biotin-PEG8-alcohol Chemical Structure

Biotin-PEG8-alcohol Chemical Structure

CAS No. : 2182601-20-1

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100 mg USD 130 In-stock
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Biotin-PEG8-alcohol Related Antibodies

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Description

Biotin-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG8-alcohol Related Antibodies
Molecular Weight

595.75

Formula

C26H49N3O10S
CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

O=C(NCCOCCOCCOCCOCCOCCOCCOCCO)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (419.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6786 mL 8.3928 mL 16.7856 mL
5 mM 0.3357 mL 1.6786 mL 3.3571 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6786 mL 8.3928 mL 16.7856 mL 41.9639 mL
5 mM 0.3357 mL 1.6786 mL 3.3571 mL 8.3928 mL
10 mM 0.1679 mL 0.8393 mL 1.6786 mL 4.1964 mL
15 mM 0.1119 mL 0.5595 mL 1.1190 mL 2.7976 mL
20 mM 0.0839 mL 0.4196 mL 0.8393 mL 2.0982 mL
25 mM 0.0671 mL 0.3357 mL 0.6714 mL 1.6786 mL
30 mM 0.0560 mL 0.2798 mL 0.5595 mL 1.3988 mL
40 mM 0.0420 mL 0.2098 mL 0.4196 mL 1.0491 mL
50 mM 0.0336 mL 0.1679 mL 0.3357 mL 0.8393 mL
60 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6994 mL
80 mM 0.0210 mL 0.1049 mL 0.2098 mL 0.5245 mL
100 mM 0.0168 mL 0.0839 mL 0.1679 mL 0.4196 mL
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Biotin-PEG8-alcohol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG8-alcohol2182601-20-1PROTAC LinkersInhibitorinhibitorinhibit

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