2. PROTAC Autophagy Apoptosis
  3. Molecular Glues Ligands for E3 Ligase Autophagy Apoptosis
  4. Biotin-Thalidomide

Biotin-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research.

For research use only. We do not sell to patients.

Biotin-Thalidomide Chemical Structure

Biotin-Thalidomide Chemical Structure

CAS No. : 2230857-87-9

Size Price Stock Quantity
1 mg USD 400 In-stock
5 mg USD 720 In-stock
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Based on 1 publication(s) in Google Scholar

Biotin-Thalidomide Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Biotin-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research.

IC50 & Target

Cereblon

 

Molecular Weight

945.09

Formula

C44H64N8O13S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(OCC(NCCCCNC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]3[C@]4([H])[C@](NC(N4)=O)([H])CS3)=O)=O)=O)=O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 125 mg/mL (132.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0581 mL 5.2905 mL 10.5810 mL
5 mM 0.2116 mL 1.0581 mL 2.1162 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.65%

COA (243 KB) HNMR (329 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 1.0581 mL 5.2905 mL 10.5810 mL 26.4525 mL
5 mM 0.2116 mL 1.0581 mL 2.1162 mL 5.2905 mL
10 mM 0.1058 mL 0.5291 mL 1.0581 mL 2.6453 mL
15 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7635 mL
20 mM 0.0529 mL 0.2645 mL 0.5291 mL 1.3226 mL
25 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0581 mL
30 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8818 mL
40 mM 0.0265 mL 0.1323 mL 0.2645 mL 0.6613 mL
50 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5291 mL
60 mM 0.0176 mL 0.0882 mL 0.1764 mL 0.4409 mL
80 mM 0.0132 mL 0.0661 mL 0.1323 mL 0.3307 mL
100 mM 0.0106 mL 0.0529 mL 0.1058 mL 0.2645 mL
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Biotin-Thalidomide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-Thalidomide2230857-87-9Molecular GluesLigands for E3 LigaseAutophagyApoptosisE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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