Biotin-Thalidomide

Cat. No.: HY-145152 Purity: 99.65%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Biotin-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research.

For research use only. We do not sell to patients.

Biotin-Thalidomide Chemical Structure

CAS No. : 2230857-87-9

Size	Price	Stock	Quantity
1 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Biotin-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research.

IC₅₀ & Target

Cereblon

Molecular Weight

945.09

Formula

C₄₄H₆₄N₈O₁₃S

CAS No.

2230857-87-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(OCC(NCCCCNC(CCCC(NCCCOCCOCCOCCCNC(CCCC[C@H]3[C@]4([H])[C@](NC(N4)=O)([H])CS3)=O)=O)=O)=O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Methanol : 125 mg/mL (132.26 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0581 mL	5.2905 mL	10.5810 mL
5 mM	0.2116 mL	1.0581 mL	2.1162 mL
10 mM	0.1058 mL	0.5291 mL	1.0581 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (264 KB) SDS (251 KB)

COA (243 KB) HNMR (329 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol	1 mM	1.0581 mL	5.2905 mL	10.5810 mL	26.4525 mL
	5 mM	0.2116 mL	1.0581 mL	2.1162 mL	5.2905 mL
	10 mM	0.1058 mL	0.5291 mL	1.0581 mL	2.6453 mL
	15 mM	0.0705 mL	0.3527 mL	0.7054 mL	1.7635 mL
	20 mM	0.0529 mL	0.2645 mL	0.5291 mL	1.3226 mL
	25 mM	0.0423 mL	0.2116 mL	0.4232 mL	1.0581 mL
	30 mM	0.0353 mL	0.1764 mL	0.3527 mL	0.8818 mL
	40 mM	0.0265 mL	0.1323 mL	0.2645 mL	0.6613 mL
	50 mM	0.0212 mL	0.1058 mL	0.2116 mL	0.5291 mL
	60 mM	0.0176 mL	0.0882 mL	0.1764 mL	0.4409 mL
	80 mM	0.0132 mL	0.0661 mL	0.1323 mL	0.3307 mL
	100 mM	0.0106 mL	0.0529 mL	0.1058 mL	0.2645 mL