Bis(methylthio)gliotoxin (Synonyms: Bisdethiobis(methylthio)gliotoxin; FR 49175; Dimethylgliotoxin)

Cat. No.: HY-N9710: FAQs
Data Sheet Handling Instructions

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Bis(methylthio)gliotoxin is a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis.

For research use only. We do not sell to patients.

Bis(methylthio)gliotoxin Chemical Structure

CAS No. : 74149-38-5

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Biological Activity
Purity & Documentation
References
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Description

Bis(methylthio)gliotoxin is a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	140 μM Compound: 3	Cytotoxicity against human Jurkat cells after 40 hrs bioluminescence assay Cytotoxicity against human Jurkat cells after 40 hrs bioluminescence assay	[PMID: 20303767]
P388	IC₅₀	0.11 μM Compound: 3	Cytotoxicity against mouse P388 cells after 96 hrs by MTT assay Cytotoxicity against mouse P388 cells after 96 hrs by MTT assay	[PMID: 22148349]

Molecular Weight

356.46

Formula

C₁₅H₂₀N₂O₄S₂

CAS No.

74149-38-5

SMILES

CS[C@]12N(C([C@@](SC)(N(C2=O)C)CO)=O)[C@@]3([H])C(C1)=CC=C[C@@H]3O

Structure Classification

Initial Source

Microorganisms

genus Aspergillus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Domingo MP, et al. Bis(methyl)gliotoxin proves to be a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis. Diagn Microbiol Infect Dis. 2012;73(1):57-64. [Content Brief]

Bis(methylthio)gliotoxin Related Classifications

Infection

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis(methylthio)gliotoxin74149-38-5Bisdethiobis(methylthio)gliotoxin FR 49175 DimethylgliotoxinFR49175FR 49175FR-49175Fungalstablereliable markerinvasive aspergillosisgliotoxindiagnosisInhibitorinhibitorinhibit

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