2. PROTAC Antibody-drug Conjugate/ADC Related
  3. PROTAC Linkers ADC Linker
  4. Bis-PEG13-NHS ester

Bis-PEG13-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Bis-PEG13-NHS ester Chemical Structure

Bis-PEG13-NHS ester Chemical Structure

CAS No. : 2221949-00-2

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Based on 1 publication(s) in Google Scholar

Bis-PEG13-NHS ester Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Bis-PEG13-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

Cleavable Linker

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-PEG13-NHS ester Related Antibodies
Molecular Weight

884.92

Formula

C38H64N2O21
CAS No.
Appearance

Solid-Liquid Mixture

Color

Colorless to off-white

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (113.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (56.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1300 mL 5.6502 mL 11.3005 mL
5 mM 0.2260 mL 1.1300 mL 2.2601 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (248 KB) HNMR (130 KB) LCMS (333 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 1.1300 mL 5.6502 mL 11.3005 mL 28.2511 mL
5 mM 0.2260 mL 1.1300 mL 2.2601 mL 5.6502 mL
10 mM 0.1130 mL 0.5650 mL 1.1300 mL 2.8251 mL
15 mM 0.0753 mL 0.3767 mL 0.7534 mL 1.8834 mL
20 mM 0.0565 mL 0.2825 mL 0.5650 mL 1.4126 mL
25 mM 0.0452 mL 0.2260 mL 0.4520 mL 1.1300 mL
30 mM 0.0377 mL 0.1883 mL 0.3767 mL 0.9417 mL
40 mM 0.0283 mL 0.1413 mL 0.2825 mL 0.7063 mL
50 mM 0.0226 mL 0.1130 mL 0.2260 mL 0.5650 mL
DMSO 60 mM 0.0188 mL 0.0942 mL 0.1883 mL 0.4709 mL
80 mM 0.0141 mL 0.0706 mL 0.1413 mL 0.3531 mL
100 mM 0.0113 mL 0.0565 mL 0.1130 mL 0.2825 mL
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Bis-PEG13-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-PEG13-NHS ester2221949-00-2PROTAC LinkersADC LinkerAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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