2. PROTAC
  3. PROTAC Linkers
  4. Bis-PEG2-acid

Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Bis-PEG2-acid Chemical Structure

Bis-PEG2-acid Chemical Structure

CAS No. : 19364-66-0

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Based on 1 publication(s) in Google Scholar

Bis-PEG2-acid Related Antibodies

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Description

Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-PEG2-acid Related Antibodies
Molecular Weight

206.19

Formula

C8H14O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCOCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (484.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8499 mL 24.2495 mL 48.4990 mL
5 mM 0.9700 mL 4.8499 mL 9.6998 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (242 KB) HNMR (121 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8499 mL 24.2495 mL 48.4990 mL 121.2474 mL
5 mM 0.9700 mL 4.8499 mL 9.6998 mL 24.2495 mL
10 mM 0.4850 mL 2.4249 mL 4.8499 mL 12.1247 mL
15 mM 0.3233 mL 1.6166 mL 3.2333 mL 8.0832 mL
20 mM 0.2425 mL 1.2125 mL 2.4249 mL 6.0624 mL
25 mM 0.1940 mL 0.9700 mL 1.9400 mL 4.8499 mL
30 mM 0.1617 mL 0.8083 mL 1.6166 mL 4.0416 mL
40 mM 0.1212 mL 0.6062 mL 1.2125 mL 3.0312 mL
50 mM 0.0970 mL 0.4850 mL 0.9700 mL 2.4249 mL
60 mM 0.0808 mL 0.4042 mL 0.8083 mL 2.0208 mL
80 mM 0.0606 mL 0.3031 mL 0.6062 mL 1.5156 mL
100 mM 0.0485 mL 0.2425 mL 0.4850 mL 1.2125 mL
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Bis-PEG2-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-PEG2-acid19364-66-0PROTAC LinkersPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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