2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Bis-PEG6-NHS ester

Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Bis-PEG6-NHS ester Chemical Structure

Bis-PEG6-NHS ester Chemical Structure

CAS No. : 1526718-98-8

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50 mg USD 25 In-stock
100 mg USD 40 In-stock
250 mg USD 80 In-stock
1 g USD 170 Get quote
5 g USD 600 Get quote
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Based on 1 publication(s) in Google Scholar

Bis-PEG6-NHS ester Related Antibodies

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Description

Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-PEG6-NHS ester Related Antibodies
Molecular Weight

576.55

Formula

C24H36N2O14
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (216.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7345 mL 8.6723 mL 17.3445 mL
5 mM 0.3469 mL 1.7345 mL 3.4689 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.28%

COA (242 KB) HNMR (117 KB) LCMS (316 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7345 mL 8.6723 mL 17.3445 mL 43.3614 mL
5 mM 0.3469 mL 1.7345 mL 3.4689 mL 8.6723 mL
10 mM 0.1734 mL 0.8672 mL 1.7345 mL 4.3361 mL
15 mM 0.1156 mL 0.5782 mL 1.1563 mL 2.8908 mL
20 mM 0.0867 mL 0.4336 mL 0.8672 mL 2.1681 mL
25 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7345 mL
30 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4454 mL
40 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0840 mL
50 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.8672 mL
60 mM 0.0289 mL 0.1445 mL 0.2891 mL 0.7227 mL
80 mM 0.0217 mL 0.1084 mL 0.2168 mL 0.5420 mL
100 mM 0.0173 mL 0.0867 mL 0.1734 mL 0.4336 mL
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Bis-PEG6-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-PEG6-NHS ester1526718-98-8ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerPEGPROTAClinkerE3ubiquitinligaseproteinnon-cleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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