2. PROTAC
  3. PROTAC Linkers
  4. Bis-propargyl-PEG4

Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Bis-propargyl-PEG4 Chemical Structure

Bis-propargyl-PEG4 Chemical Structure

CAS No. : 159428-42-9

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Based on 1 publication(s) in Google Scholar

Bis-propargyl-PEG4 Related Antibodies

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Description

Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

Bis-propargyl-PEG4 can be used in the synthesis of demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-propargyl-PEG4 Related Antibodies
Molecular Weight

270.32

Formula

C14H22O5
CAS No.
Appearance

Liquid (Density: 1.043±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

C#CCOCCOCCOCCOCCOCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (369.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6993 mL 18.4966 mL 36.9932 mL
5 mM 0.7399 mL 3.6993 mL 7.3986 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6993 mL 18.4966 mL 36.9932 mL 92.4830 mL
5 mM 0.7399 mL 3.6993 mL 7.3986 mL 18.4966 mL
10 mM 0.3699 mL 1.8497 mL 3.6993 mL 9.2483 mL
15 mM 0.2466 mL 1.2331 mL 2.4662 mL 6.1655 mL
20 mM 0.1850 mL 0.9248 mL 1.8497 mL 4.6241 mL
25 mM 0.1480 mL 0.7399 mL 1.4797 mL 3.6993 mL
30 mM 0.1233 mL 0.6166 mL 1.2331 mL 3.0828 mL
40 mM 0.0925 mL 0.4624 mL 0.9248 mL 2.3121 mL
50 mM 0.0740 mL 0.3699 mL 0.7399 mL 1.8497 mL
60 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5414 mL
80 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1560 mL
100 mM 0.0370 mL 0.1850 mL 0.3699 mL 0.9248 mL
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Bis-propargyl-PEG4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-propargyl-PEG4159428-42-9PROTAC LinkersenterococcusfaecalisdemethylvancomycindimersInhibitorinhibitorinhibit

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