2. Cytoskeleton Metabolic Enzyme/Protease
  3. Dynamin HIV Integrase
  4. Bis-T-23

Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD).

For research use only. We do not sell to patients.

Bis-T-23 Chemical Structure

Bis-T-23 Chemical Structure

CAS No. : 171674-76-3

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1 mg USD 350 In-stock
5 mg USD 828 In-stock
10 mg USD 1130 In-stock
25 mg USD 1750 In-stock
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Based on 1 publication(s) in Google Scholar

Bis-T-23 Related Antibodies

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Description

Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD)[1][2].

In Vitro

Bis-T-23 (AG1717) (0.18 μM) can inhibit HIV-1 integrase[2].
AG1717 (2 μM) can inhibit binding of integrase to the substrate DNA[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis-T-23 Related Antibodies
In Vivo

Bis-T-23 (AG1717) (1 ng) targets actin-dependent dynamin oligomerization in podocytes to promote proper GFB function[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorate proteinuria by altering actin dynamics[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorates or prevented proteinuria and diminished mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (8 weeks old, males); Mice[1]
Dosage: 20, 40 mg/kg; 40 mg/kg
Administration: Intraperitoneal injection; signle, once for 6 consecutive days
Result: Specifically reduced proteinuria on days 18 and 24.
Caused a transient reduction of proteinuria (single dose) in PKCε KO mice.
Completely prevented the onset of high-level proteinuria in the CD2AP KO mice.
Significantly extended the lifespans of CD2AP KO mice.
Led to improved glomerular histology with less mesangial matrix accumulation.
Animal Model: Zebrafish[1]
Dosage: 1 ng
Administration: Injection
Result: Promoted oligomerization of zebrafish Dyn2.
Increased the number of focal adhesions (FAs) and stress fibers in cultured podocytes.
Molecular Weight

480.43

Formula

C23H20N4O8
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(/C(C#N)=C/C1=CC(O)=C(C(O)=C1)O)NCCCNC(/C(C#N)=C/C2=CC(O)=C(C(O)=C2)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (208.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0815 mL 10.4073 mL 20.8147 mL
5 mM 0.4163 mL 2.0815 mL 4.1629 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0815 mL 10.4073 mL 20.8147 mL 52.0367 mL
5 mM 0.4163 mL 2.0815 mL 4.1629 mL 10.4073 mL
10 mM 0.2081 mL 1.0407 mL 2.0815 mL 5.2037 mL
15 mM 0.1388 mL 0.6938 mL 1.3876 mL 3.4691 mL
20 mM 0.1041 mL 0.5204 mL 1.0407 mL 2.6018 mL
25 mM 0.0833 mL 0.4163 mL 0.8326 mL 2.0815 mL
30 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
40 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3009 mL
50 mM 0.0416 mL 0.2081 mL 0.4163 mL 1.0407 mL
60 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8673 mL
80 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6505 mL
100 mM 0.0208 mL 0.1041 mL 0.2081 mL 0.5204 mL
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Bis-T-23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-T-23171674-76-3AG1717AG 1717AG-1717DynaminHIV Integrasechronic kidney diseases (CKD)proteinuriaglomerular filtration barrier (GFB)dynaminactin cytoskeletonHIV integraseInhibitorinhibitorinhibit

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