2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Bivamelagon

Bivamelagon  (Synonyms: MC-4R Agonist 2)

Cat. No.: HY-153660 Purity: 98.72%
COA Handling Instructions

Molarity Calculator

MC-4R Agonist 2 (Example 1) is a MC4R agonist. MC-4R Agonist 2 can be used in the study of obesity, diabetes, inflammation, and erectile dysfunction.

For research use only. We do not sell to patients.

Bivamelagon Chemical Structure

Bivamelagon Chemical Structure

CAS No. : 2641595-54-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1135 In-stock
Solution
10 mM * 1 mL in DMSO USD 1135 In-stock
Solid
1 mg USD 320 In-stock
5 mg USD 820 In-stock
10 mg USD 1340 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Bivamelagon:

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Description

MC-4R Agonist 2 (Example 1) is a MC4R agonist. MC-4R Agonist 2 can be used in the study of obesity, diabetes, inflammation, and erectile dysfunction[1].

IC50 & Target

MC-4R[1].
Molecular Weight

629.27

Formula

C35H53ClN4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1[C@H](C2=CC=C(C=C2)Cl)CN(C1)C(C)(C)C)N3[C@@H](C[C@@H](C3)N([C@@H]4CC[C@@H](CC4)C)C(C(C)C)=O)C(N5CCOCC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (198.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5891 mL 7.9457 mL 15.8914 mL
5 mM 0.3178 mL 1.5891 mL 3.1783 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.50%

COA (260 KB) HNMR (276 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5891 mL 7.9457 mL 15.8914 mL 39.7286 mL
5 mM 0.3178 mL 1.5891 mL 3.1783 mL 7.9457 mL
10 mM 0.1589 mL 0.7946 mL 1.5891 mL 3.9729 mL
15 mM 0.1059 mL 0.5297 mL 1.0594 mL 2.6486 mL
20 mM 0.0795 mL 0.3973 mL 0.7946 mL 1.9864 mL
25 mM 0.0636 mL 0.3178 mL 0.6357 mL 1.5891 mL
30 mM 0.0530 mL 0.2649 mL 0.5297 mL 1.3243 mL
40 mM 0.0397 mL 0.1986 mL 0.3973 mL 0.9932 mL
50 mM 0.0318 mL 0.1589 mL 0.3178 mL 0.7946 mL
60 mM 0.0265 mL 0.1324 mL 0.2649 mL 0.6621 mL
80 mM 0.0199 mL 0.0993 mL 0.1986 mL 0.4966 mL
100 mM 0.0159 mL 0.0795 mL 0.1589 mL 0.3973 mL
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Bivamelagon Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bivamelagon2641595-54-0MC-4R Agonist 2Melanocortin ReceptorMC Receptorobesitydiabetesinflammationerectile dysfunctionInhibitorinhibitorinhibit

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