2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein Immunology/Inflammation
  3. GABA Receptor 5-HT Receptor Dopamine Receptor Histamine Receptor
  4. BL-1020 mesylate

BL-1020 mesylate is the mesylate salt form of BL-1020. BL-1020 mesylate is an antipsychotic agent. BL-1020 mesylate is inhibitor for dopamine receptor and serotonin receptor (5-HT receptor), with Ki of 0.066, 0.062 and 0.21 nM, for D2L, D2S and 5-HT2A receptors, respectively. BL-1020 mesylate is agonist for GABAA receptor with Ki of 3.74 μM, and enhances the GABA release. BL-1020 mesylate exhibits high affinity with histamine receptor (Ki is 0.47 nM). BL-1020 mesylate reduces Amphetamine-induced hyperactivity, with lower catalepsy and sedation. BL-1020 mesylate is blood-brain barrier penetrate.

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BL-1020 mesylate Chemical Structure

BL-1020 mesylate Chemical Structure

CAS No. : 916898-61-8

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BL-1020 mesylate Related Antibodies

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Description

BL-1020 mesylate is the mesylate salt form of BL-1020. BL-1020 mesylate is an antipsychotic agent. BL-1020 mesylate is inhibitor for dopamine receptor and serotonin receptor (5-HT receptor), with Ki of 0.066, 0.062 and 0.21 nM, for D2L, D2S and 5-HT2A receptors, respectively. BL-1020 mesylate is agonist for GABAA receptor with Ki of 3.74 μM, and enhances the GABA release. BL-1020 mesylate exhibits high affinity with histamine receptor (Ki is 0.47 nM). BL-1020 mesylate reduces Amphetamine-induced hyperactivity, with lower catalepsy and sedation. BL-1020 mesylate is blood-brain barrier penetrate[1].

IC50 & Target

D2L Receptor

0.066 nM (Ki)

Histamine Receptor

0.47 nM (Ki)

5-HT2A Receptor

3.74 μM (Ki)

Molecular Weight

585.18

Formula

C26H37ClN4O5S2
CAS No.
SMILES

O=C(CCCN)OCCN1CCN(CCCN2C3=C(SC4=CC=C(C=C42)Cl)C=CC=C3)CC1.O=S(O)(C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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BL-1020 mesylate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BL-1020916898-61-8BL1020BL 1020GABA Receptor5-HT ReceptorDopamine ReceptorHistamine ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorschizophreniaantipsychoticcatalepsyBBB penetrateWistar ratsInhibitorinhibitorinhibit

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