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BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux.

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BMS-195270 Chemical Structure

BMS-195270 Chemical Structure

CAS No. : 202822-23-9

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5 mg USD 175 In-stock
10 mg USD 280 In-stock
25 mg USD 560 In-stock
50 mg USD 900 In-stock
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Based on 1 publication(s) in Google Scholar

BMS-195270 Related Antibodies

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Description

BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux[1].

In Vitro

BMS-195270 (3 μM) produces a dramatic reduction in developed pressure at infusion volumes of 0.2-1.3 mL and inhibits spontaneous contractions in an ex vivo rat whole bladder model[1].
BMS-195270 (2.8 mM) results adult worms of C. elegans displaying an Egl-d phenotype, as well as slowed or arrested pharyngeal pumping (Eat), and uncoordinated motion (Unc)[1].
BMS-195270 inhibits the response of HEK293 cells to the muscarinic agonist Carbachol (HY-B1208) with an EC50 of 2 μM[1].
BMS-195270 inhibits calcium flux, and retains inhibitory activity even when endogenous calcium channels are inactivated[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-195270 Related Antibodies
Molecular Weight

355.70

Formula

C15H9ClF3N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C2=CC(Cl)=CC=C2O)NC(C3=CC=CC=C3C(F)(F)F)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (351.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8114 mL 14.0568 mL 28.1136 mL
5 mM 0.5623 mL 2.8114 mL 5.6227 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8114 mL 14.0568 mL 28.1136 mL 70.2839 mL
5 mM 0.5623 mL 2.8114 mL 5.6227 mL 14.0568 mL
10 mM 0.2811 mL 1.4057 mL 2.8114 mL 7.0284 mL
15 mM 0.1874 mL 0.9371 mL 1.8742 mL 4.6856 mL
20 mM 0.1406 mL 0.7028 mL 1.4057 mL 3.5142 mL
25 mM 0.1125 mL 0.5623 mL 1.1245 mL 2.8114 mL
30 mM 0.0937 mL 0.4686 mL 0.9371 mL 2.3428 mL
40 mM 0.0703 mL 0.3514 mL 0.7028 mL 1.7571 mL
50 mM 0.0562 mL 0.2811 mL 0.5623 mL 1.4057 mL
60 mM 0.0469 mL 0.2343 mL 0.4686 mL 1.1714 mL
80 mM 0.0351 mL 0.1757 mL 0.3514 mL 0.8785 mL
100 mM 0.0281 mL 0.1406 mL 0.2811 mL 0.7028 mL
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BMS-195270 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-195270202822-23-9BMS195270BMS 195270OtherscontractionC. elegansCarbacholHEK293calcium fluxInhibitorinhibitorinhibit

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